Infernal 1.1: RNA alignment and database search, 10,000x faster

One of our lab's goals is to make it possible to systematically search for homologs of RNAs in genomes, not just by looking for sequence conservation but also by looking for RNA secondary structure conservation. A powerful model framework for RNA structure/sequence comparison, called profile stochastic-context free grammars (profile SCFGs), was introduced in the mid-1990s … Continue reading Infernal 1.1: RNA alignment and database search, 10,000x faster

Infernal 1.0

Infernal 1.0 -- the first production release of our software for RNA sequence/structure homology search and alignment -- has been released. Source code and documentation are available over at infernal.janelia.org. Infernal development is now led by Eric Nawrocki in the lab. Infernal's actually been used by the Rfam database since about 2002, in pre-1.0 versions. … Continue reading Infernal 1.0