Astronomy began when the Babylonians mapped the heavens. Our descendants will certainly not say that biology began with today’s genome projects, but they may well recognize that a great acceleration in the accumulation of biological knowledge began in our era.
Graeme Mitchison wrote those opening lines of our book Biological Sequence Analysis in Richard Durbin’s parents’ house in London. We four coauthors had borrowed the house for a month to write together, knowing that we had to get Richard out of the Sanger Centre or no progress would be made. The living room looked like a spy ring’s safe house, drapes drawn and full of improvised desks, computers, printer, and papers. We paired off in warring alliances to write, to cook, to argue, and to take long walks on the Hampstead Heath to cool down. At one point over a late dinner and wine, Anders Krogh proposed that one could make a hidden Markov model to recognize each of our writing styles. Richard proposed that mine could be recognized trivially by a high emission probability of the word “simple”. I recall snapping something back. I was struggling to draft our introduction and feeling defensive. At some point Graeme took it from me and in a few strokes replaced my clumsy efforts with the chapter that began with the beautiful lines above.